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Research programme 01
Mutant p53 biology
We examine how different TP53 mutations combine loss of tumor-suppressive activity with mutation-specific, context-dependent neomorphic functions.
TP53 mutations are remarkably diverse. The laboratory studies missense, frameshift and other cancer-associated variants to distinguish simple loss of wild-type function from new activities acquired by mutant proteins.
Recent genomic work asks how mutant p53 occupies chromatin, regulates distinct gene sets and cooperates with cellular context. The aim is a functional map that is more informative than treating all TP53-mutant cancers as one biological class.
