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Research programme 02
DNA-damage checkpoints
We define how p53 coordinates reversible arrest, mitotic entry and recovery after transient or sustained genotoxic stress.
The laboratory has long investigated p53-dependent control of G1 and G2/M checkpoints. This work connects transcriptional repression of mitotic regulators with post-transcriptional mechanisms that determine whether damaged cells arrest, repair or die.
Representative targets include CDC25C, survivin, CDC20 and cyclin B1. Their regulation provides a mechanistic route to understand why p53-defective tumor cells respond differently to DNA-damaging treatment.
